AustralieFrV1, Main, Exploration, bibRecord, 006A61

HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

Identifieur interne : 006A61 ( Main/Exploration ); précédent : 006A60; suivant : 006A62

HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

Auteurs : Delphine Sauce [France] ; Martin Larsen [France] ; Solène Fastenackels [France] ; Michèle Pauchard [France] ; Hocine Ait-Mohand [France] ; Luminita Schneider [France] ; Amélie Guihot [France] ; Faroudy Boufassa [France] ; John Zaunders [Australie] ; Malika Iguertsira [France] ; Michelle Bailey [Australie] ; Guy Gorochov [France] ; Claudine Duvivier [France] ; Guislaine Carcelain [France] ; Anthony D. Kelleher [Australie] ; Anne Simon [France] ; Laurence Meyer [France] ; Dominique Costagliola [France] ; Steven G. Deeks [États-Unis] ; Olivier Lambotte [France] ; Brigitte Autran [France] ; Peter W. Hunt [États-Unis] ; Christine Katlama [France] ; Victor Appay [France]

Source :

Blood [ 0006-4971 ] ; 2011.

RBID : Pascal:11-0244769

Descripteurs français

Pascal (Inist)
- SIDA, Virus, Réplication, Lymphopoïèse, Hématologie.

English descriptors

KwdEn :
- AIDS, Hematology, Lymphopoiesis, Replication, Virus.

Abstract

The mechanisms of CD4⁺ T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4⁺ T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4⁺ T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34⁺ hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109539

Affiliations:

Le document en format XML

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<author><name sortKey="Boufassa, Faroudy" sort="Boufassa, Faroudy" uniqKey="Boufassa F" first="Faroudy" last="Boufassa">Faroudy Boufassa</name>
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<author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name>
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<author><name sortKey="Iguertsira, Malika" sort="Iguertsira, Malika" uniqKey="Iguertsira M" first="Malika" last="Iguertsira">Malika Iguertsira</name>
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<author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name>
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<author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name>
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<author><name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name>
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<author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name>
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<author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name>
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<author><name sortKey="Simon, Anne" sort="Simon, Anne" uniqKey="Simon A" first="Anne" last="Simon">Anne Simon</name>
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<author><name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name>
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<sZ>8 aut.</sZ>
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<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Assistance Publique-Hopitaux (AP-HP), Service d'Epiděmiologie et de Santě Publique, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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</inist:fA14>
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</affiliation>
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<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
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<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
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<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
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<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
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</affiliation>
</author>
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<author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name>
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<sZ>4 aut.</sZ>
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<placeName><region type="region">Île-de-France</region>
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</placeName>
</affiliation>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
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<author><name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
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<placeName><region type="region">Île-de-France</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis</title>
<author><name sortKey="Sauce, Delphine" sort="Sauce, Delphine" uniqKey="Sauce D" first="Delphine" last="Sauce">Delphine Sauce</name>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
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</inist:fA14>
<country>France</country>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Fastenackels, Solene" sort="Fastenackels, Solene" uniqKey="Fastenackels S" first="Solène" last="Fastenackels">Solène Fastenackels</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<region type="old region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Pauchard, Michele" sort="Pauchard, Michele" uniqKey="Pauchard M" first="Michèle" last="Pauchard">Michèle Pauchard</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ait Mohand, Hocine" sort="Ait Mohand, Hocine" uniqKey="Ait Mohand H" first="Hocine" last="Ait-Mohand">Hocine Ait-Mohand</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
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<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schneider, Luminita" sort="Schneider, Luminita" uniqKey="Schneider L" first="Luminita" last="Schneider">Luminita Schneider</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guihot, Amelie" sort="Guihot, Amelie" uniqKey="Guihot A" first="Amélie" last="Guihot">Amélie Guihot</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boufassa, Faroudy" sort="Boufassa, Faroudy" uniqKey="Boufassa F" first="Faroudy" last="Boufassa">Faroudy Boufassa</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>St Vincent's Centre for Applied Medical Research and University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iguertsira, Malika" sort="Iguertsira, Malika" uniqKey="Iguertsira M" first="Malika" last="Iguertsira">Malika Iguertsira</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>St Vincent's Centre for Applied Medical Research and University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Immunoregulation and Immunotherapy, Inserm UMR S 945, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitiě-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Assistance Publique-Hopitaux (AP-HP), Groupe hospitalier Necker-Enfant malades, Service de Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Universitě Descartes</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Institut Pasteur, Centre Medical de l'Institut Pasteur; Centre d'Infectiologie Necker-Pasteur, Děpartement Infection et Epiděmiologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>St Vincent's Centre for Applied Medical Research and University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simon, Anne" sort="Simon, Anne" uniqKey="Simon A" first="Anne" last="Simon">Anne Simon</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Service de Mědecine Interne</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Inserm U1018, Universitě Paris-Sud, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Assistance Publique-Hopitaux (AP-HP), Service d'Epiděmiologie et de Santě Publique, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deeks, Steven G" sort="Deeks, Steven G" uniqKey="Deeks S" first="Steven G." last="Deeks">Steven G. Deeks</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>San Francisco, CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>Inserm U802, Universite Paris-Sud, Hôpital Bicêtre</s1>
<s2>Le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital Bicêtre</wicri:noRegion>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>HIV/AIDS Division, Department of Internal Medicine, University of California San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>San Francisco, CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Inserm UMR S 943, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiê-Salpêtrière, Service des Maladies Infectieuses et Tropicales</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Inserm UMR S 945, Infections and Immunity, Avenir Group, Universitě Pierre et Marie Curie-Paris 6, Hôpital Pitie-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Assistance Publique-Hopitaux de Paris (AP-HP), Groupe hospitalier Pitiě-Salpêtrière, Laboratoire d'Immunologie Cellulaire et Tissulaire</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Hematology</term>
<term>Lymphopoiesis</term>
<term>Replication</term>
<term>Virus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term>
<term>Virus</term>
<term>Réplication</term>
<term>Lymphopoïèse</term>
<term>Hématologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The mechanisms of CD4<sup>+</sup>
 T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4<sup>+</sup>
 T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4<sup>+</sup>
 T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34<sup>+</sup>
 hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Orsay</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Sauce, Delphine" sort="Sauce, Delphine" uniqKey="Sauce D" first="Delphine" last="Sauce">Delphine Sauce</name>
</region>
<name sortKey="Ait Mohand, Hocine" sort="Ait Mohand, Hocine" uniqKey="Ait Mohand H" first="Hocine" last="Ait-Mohand">Hocine Ait-Mohand</name>
<name sortKey="Ait Mohand, Hocine" sort="Ait Mohand, Hocine" uniqKey="Ait Mohand H" first="Hocine" last="Ait-Mohand">Hocine Ait-Mohand</name>
<name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name>
<name sortKey="Appay, Victor" sort="Appay, Victor" uniqKey="Appay V" first="Victor" last="Appay">Victor Appay</name>
<name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<name sortKey="Boufassa, Faroudy" sort="Boufassa, Faroudy" uniqKey="Boufassa F" first="Faroudy" last="Boufassa">Faroudy Boufassa</name>
<name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name>
<name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name>
<name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name>
<name sortKey="Costagliola, Dominique" sort="Costagliola, Dominique" uniqKey="Costagliola D" first="Dominique" last="Costagliola">Dominique Costagliola</name>
<name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name>
<name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name>
<name sortKey="Duvivier, Claudine" sort="Duvivier, Claudine" uniqKey="Duvivier C" first="Claudine" last="Duvivier">Claudine Duvivier</name>
<name sortKey="Fastenackels, Solene" sort="Fastenackels, Solene" uniqKey="Fastenackels S" first="Solène" last="Fastenackels">Solène Fastenackels</name>
<name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name>
<name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name>
<name sortKey="Guihot, Amelie" sort="Guihot, Amelie" uniqKey="Guihot A" first="Amélie" last="Guihot">Amélie Guihot</name>
<name sortKey="Guihot, Amelie" sort="Guihot, Amelie" uniqKey="Guihot A" first="Amélie" last="Guihot">Amélie Guihot</name>
<name sortKey="Iguertsira, Malika" sort="Iguertsira, Malika" uniqKey="Iguertsira M" first="Malika" last="Iguertsira">Malika Iguertsira</name>
<name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name>
<name sortKey="Lambotte, Olivier" sort="Lambotte, Olivier" uniqKey="Lambotte O" first="Olivier" last="Lambotte">Olivier Lambotte</name>
<name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name>
<name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name>
<name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name>
<name sortKey="Meyer, Laurence" sort="Meyer, Laurence" uniqKey="Meyer L" first="Laurence" last="Meyer">Laurence Meyer</name>
<name sortKey="Pauchard, Michele" sort="Pauchard, Michele" uniqKey="Pauchard M" first="Michèle" last="Pauchard">Michèle Pauchard</name>
<name sortKey="Pauchard, Michele" sort="Pauchard, Michele" uniqKey="Pauchard M" first="Michèle" last="Pauchard">Michèle Pauchard</name>
<name sortKey="Schneider, Luminita" sort="Schneider, Luminita" uniqKey="Schneider L" first="Luminita" last="Schneider">Luminita Schneider</name>
<name sortKey="Schneider, Luminita" sort="Schneider, Luminita" uniqKey="Schneider L" first="Luminita" last="Schneider">Luminita Schneider</name>
<name sortKey="Simon, Anne" sort="Simon, Anne" uniqKey="Simon A" first="Anne" last="Simon">Anne Simon</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name>
</region>
<name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name>
<name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Deeks, Steven G" sort="Deeks, Steven G" uniqKey="Deeks S" first="Steven G." last="Deeks">Steven G. Deeks</name>
</noRegion>
<name sortKey="Hunt, Peter W" sort="Hunt, Peter W" uniqKey="Hunt P" first="Peter W." last="Hunt">Peter W. Hunt</name>
</country>
</tree>
</affiliations>
</record>

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   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:11-0244769
   |texte=   HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
}}

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Serveur d'exploration sur les relations entre la France et l'Australie

HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

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	Serveur d'exploration sur les relations entre la France et l'Australie
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